Actuarial Criteria for Diagnosis of Mild Cognitive Impairment and Dementia in
Racially/Ethnically Diverse Older Adults 


   Note: An Official Proposal has not been Submitted to NACC.


   Lead Investigator:    Lisa Graves
   Institution      :    VA San Diego/UC San Diego
   E-Mail           :    lvgraves@gmail.com
   Proposal ID      :    1699



   Proposal Description:
   Previous work from our laboratory has demonstrated that the application of actuarial criteria for the diagnosis of mild cognitive impairment (MCI) and dementia may offer a better balance of sensitivity and specificity and improve Alzheimer's disease biomarker associations compared to consensus or other conventional diagnostic methods (Bondi et al., 2014 Edmonds et al., 2015 Jak et al., 2009 Graves et al., 2020). However, these studies have been based largely on homogeneous samples and what remains unclear is whether the utility of these methods generalizes to racially/ethnically diverse older adults, including Black/African Americans. Using clinical,  cognitive/neuropsychological, functional, and biomarker data from the NACC, we propose to examine: (1) MCI and dementia prevalence using actuarial and NACC consensus diagnostic methods, (2) associations between reported functioning and neuropsychological performance, and (3) biomarker associations in racially/ethnically diverse older adults in the NACC cohort.